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发布于:2018-2-10 09:36:17  访问:34 次 回复:0 篇
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Quency of NY-ESO-1 33 Diagnostic approach PCR
Figures two, 3 and 4 outline theclassificationoftumor-infiltratinglymphocytes(TIL),whichis becoming increasingly essential in the study of cancers. Recently, 1 study concluded that high-grade tumor-infiltrating lymphocytes (brisk) in principal melanoma is linked with a reduced threat of death irrespective of the tumor characteristics which are presently used by the American Joint Committee on Cancer (AJCC).87 In other research, the presence of TIL in melanoma gave sufferers superior prognosis.10Thetypeoftu.Quency of NY-ESO-1 33 Diagnostic method PCR Associations found (p0.05) Authors Goydos et al.,46 generally 37 13 32 19IHC IHC IHC> Breslow > Breslow RFS > BreslowBarrow et al., 2006 Svobodova et al., 2011 Velasquez et al.,IHC> Breslow sup. ext. CD3+Giavina-Bianchi et al.,IHC=Immunohistochemistry;RFS=relapsefreesurvival;sup.ext.=SuperficialextensivehistologicaltypeAn Bras Dermatol. 2017;92(2):156-66.Melanoma: tumor microenvironment and new treatmentsWhen analyzing the presence of ulceration in the tumor in relation towards the positivity in the NY-ESO-1 protein, two studies evidenced a tendency to good association, but there was no statistical significance.71,75 The amount of mitoses in melanoma was not linked using the presence of NY-ESO-1 within the only study in which it was tested. Despite the fact that investigations indicate that the presence of NYESO-1 is related with thicker tumors, and they are much more regularly causing metastasis, there was no statistical difference in sentinel lymph node status or within the development of metastases of patients in relation to the presence on the antigen.71,75 Asfordisease-specificsurvivalofpatients,moststudieshave associated the presence with the expression in the Cancer-Testis antigens to a worse prognosis inside a range of cancers, for example neuroblastoma, ovarian cancer, breast cancer, many myeloma, and others.77-80 In melanomas, some studies have demonstrated the identical association, 72-74 but other individuals didn‘t show statistical difference between the groups.71,75 Antigen NY-ESO-1 along with the immune response The NY-ESO-1 antigen could be the most immunogenic in the Cancer-Testis antigens recognized to date. Humoral and cellular responses with CD4 and CD8 lymphocytes are observed in about 5 to 15 of sufferers with distinct kinds of tumors.81,82 Nonetheless, when analyzing patients with NY-ESO-1 good tumors, this frequency rises to 50 .83 The humoral response to NY-ESO-1 is diverse in relation to the class of immunoglobulin synthesized, being IgG1, IgG2, IgG3 and/or IgG4, which are regularly detected simultaneously in the patients serum, as well as the IgG1 isotype will be the most frequent of them.57 Titers against NY-ESO-1 could be extremely higher, being detected at a dilution of 1/1,000,000 inside the ELISA, while most are among 1/6,400 and 1/100,000. No in vivo function for these antibodies has yet been demonstrated, as we understand that their targets usually are not accessible, since the expression of NY-ESO-1 in tumor cells is cytoplasmic. Not too long ago, a single study concluded that high-grade tumor-infiltrating lymphocytes (brisk) in key melanoma is linked using a lower Impacted by it can be worth additional consideration. Moreover, examining the danger of death no matter the tumor qualities that happen to be currently utilised by the American Joint Committee on Cancer (AJCC).87 In other studies, the presence of TIL in melanoma gave sufferers better prognosis.10Thetypeoftu.
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