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发布于:2018-3-9 10:45:05  访问:3 次 回复:0 篇
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Are Inhibitor Library Actually Worth The Dough?
A novel resonant inductive decoupling (RID) method, which allows compensation for both reactive and resistive components of the mutual impedance between the adjacent surface coils, has been developed and verified experimentally. This method provides an easy way to adjust the decoupling remotely by changing the resonance frequency of the RID circuit through the adjustment of a variable capacitor. As an example, a single-row (1?��?16) 7-T transceiver head array of n?=?16 small overlapped check details surface coils using RID decoupling between adjacent coils was built. In combination with overlapped coils, the RID technique achieved better than �C24?dB of decoupling for all adjacent coils. Copyright ? 2013 John Wiley & Sons, Ltd. ""The aim of the study was the testing of sustained intrapericardial delivery of vascular growth factors (GFs) from alginate beads on cryoinjury size and perfusion. In domestic pigs (15�C20?kg, n?=?21), the left ventricular (LV) anterolateral wall of exposed hearts was cryoinjured using an aluminum rod (25?mm o.d.) cooled in liquid nitrogen. Alginate beads (d?=?3.2?��?0.2?mm), containing human recombinant basic fibroblast GF (bFGF, 50??g) and vascular endothelial GF (VEGF, 50??g)?+?heparin (50??g) or heparin alone (Con, n?=?5), were sutured to the cryoinjured epicardium (GF, n?=?5; Con, n?=?3 ) or pericardium (GF, n?=?3; Con, n?=?2), or no beads were implanted (n?=?4). Four Tasisulam pigs were sham-operated. Cine and T1-weighted MRI was performed in vivo at ~2.5?h and 1, phosphatase inhibitor library 2, 3 and 4?weeks after injury in a 3T imager. A double bolus of GdDTPA was injected (0.05 and 0.15?mmol/kg) and first-pass and late enhancement kinetics were monitored. After 4-week cryoinjury, following the injection of 5x106 15-?m NIR fluorescent microspheres (FMS, 645/680?nm), hearts were sliced and examined with fluorescence imaging. Triphenyltetrazolium chloride (TTC) staining was used to determine infarct areas. Epicardial GF-containing beads were encapsulated within the hypointense 3-4-week infarct tissue. This tissue had a 75% higher LV thickening index, a lower distribution volume for GdDTPA (0.44?��?0.12 vs 0.68?��?0.05, p?=?0.02), and 25% faster first-pass Gd kinetics relative to control infarctions. TTC staining revealed TTC-positive islands in the core of treated infarcts, which showed higher FMS fluorescence relative to surrounding infarct tissue (0.64?��?0.14 vs. 0.31?��?0.14; p?
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