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发布于:2018-3-9 13:54:36  访问:7 次 回复:0 篇
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Rapamycin : An Unmistakable Level of comfort!
GAPDH was used as a housekeeping gene for normalization, and a ��no template�� sample was used as a negative control. For continuous variables, results are expressed as medians and interquartile ranges, or in box-and-whisker plots. In continuous variables, when comparisons were made between groups, the Kruskal�CWallis H-test was used to assess significant intergroup variability. Bleomycin The Mann�CWhitney U 2-tailed test was used for between-group comparison. Differences in proportions between groups were tested by chi-square test. Bonferroni correction was used to adjust significance levels for multiple comparisons between different groups using an ��?=?0.05/7?=?0.0071 for each comparison. The Spearman test was used to determine correlations, and significance was accepted for P?Selleckchem MG 132 incidence of glandular hyperplastic selleck kinase inhibitor type tended to increase from eosinophilic CRSwNP [16.7% (12/72)] to noneosinophilic CRSwNP [19.7% (15/76)] and to CRSsNP [30.6% (22/72)], there was no significant difference among them. Furthermore, we found that the total collagen amount was significantly lower in eosinophilic and noneosinophilic CRSwNP and significantly higher in CRSsNP compared with controls (Fig.?1). Although both eosinophilic and noneosinophilic CRSwNP had a reduced deposition of collagen compared with CRSsNP and controls, noneosinophilic CRSwNP had a relatively higher amount of collagen compared with eosinophilic CRSwNP (Fig.?1). In contrast, the edema scores were significantly higher in eosinophilic and noneosinophilic CRSwNP than in CRSsNP and controls and were further increased in eosinophilic CRSwNP compared with noneosinophilic CRSwNP (Fig.?1). The number of ��-SMA-positive myofibroblasts was significantly higher in all types of CRS compared with controls (Fig. S1). Although there was a trend toward increased number of myofibroblasts from eosinophilic CRSwNP to noneosinophilic CRSwNP and to CRSsNP, only the difference between eosinophilic CRSwNP and CRSsNP reached the statistical significance (Fig. S1). The expression pattern of fibronectin in different types of CRS was consistent with that of ��-SMA (Fig. S1). We investigated expression of TGF-�� isoforms including TGF-��1, TGF-��2, and TGF-��3. As illustrated in Fig.
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