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发布于:2019-1-8 10:39:21  访问:22 次 回复:0 篇
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Hi M, <a href="https://www.ncbi.nlm.nih.gov/pubmed
Lax SF, Kendall B, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28914615 Tashiro H, Slebos RJC, Ellenson LH: The frequency of p53, K-ras mutations, and microsatellite instability differs in CS-7593 site uterine endometrioid and serous carcinoma - Evidence of distinct molecular genetic pathways. Shi ZA, Derow CK, Zhang B: Co-expression module analysis reveals biological processes, genomic achieve, and regulatory mechanisms associated with breast cancer progression. BMC Syst Biol 2010, 4:74. 16. Ma SG, Huang Y, Huang J, Fang KN: Gene network-based cancer prognosis evaluation with sparse boosting. Genet Res 2012, 94(4):205?21. 17. Levine AJ, Miller JA, Shapshak P, Gelman B, Singer EJ, Hinkin CH, Commins D, Morgello S, Grant I, Horvath S: Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairmentClassification overall performance was assessed with regions beneath the receiving operating characteristic (AUC) curve. Employing the penalized logistic regression by means of the elastic-net, a classification model was built, and its discriminatory capacity was 1st estimated with a strict 10-fold cross-validation methodology (as described in Added file 1: Materials and Approaches). The resulting model was next tested on independent datasets making use of the cancer hub genes as a model input to predict the classes of specific samples relevant towards the procedure of neoplastic transformation and progression in ECs.Pathway analysisThe network was visualized by means of Cytoscape Software program three.0.1 [48].Hi M, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28388412 Okai T: Genetics of endometrial cancers. Obstet Gynecol Int 2010, 2010:1?. five. Lax SF, Kendall B, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28914615 Tashiro H, Slebos RJC, Ellenson LH: The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma - Proof of distinct molecular genetic pathways. Cancer 2000, 88(four):814?24. 6. Bansal N, Yendluri V, Wenham RM: The molecular biology of endometrial cancers plus the implications for pathogenesis, classification, and targeted therapies. Cancer Handle 2009, 16(1):eight?three. 7. Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JPA, Lees JA, Weng LP, Eng C: Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer I 2000, 92(11):924?31. 8. Ryan AJ, Susil B, Jobling TW, Oehler MK: Endometrial cancer. Cell Tissue Res 2005, 322(1):53?1. 9. Enomoto T, Inoue M, Perantoni AO, Buzard GS, Miki H, Tanizawa O, Rice JM: K-ras activation in premalignant and malignant epithelial lesions from the human uterus. Cancer Res 1991, 51(19):5308?314. ten. Risinger JI, Hayes AK, Berchuck A, Barrett JC: PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 1997, 57(21):4736?738. 11. Odicino FE, Bignotti E, Rossi E, Pasinetti B, Tassi RA, Donzelli C, Falchetti M, Fontana P, Grigolato PG, Pecorelli S: HER-2/neu overexpression and amplification in uterine serous papillary carcinoma: comparative analysis of immunohistochemistry, real-time reverse transcription-polymerase chain reaction, and fluorescence in situ hybridization. Int J Gynecol Cancer 2008, 18(1):14?1. 12. Miller JA, Horvath S, Geschwind DH: Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc Natl Acad Sci U S A 2010, 107(28):12698?2703. 13.
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